University of Geneva

The co-occurrence of ASD and epilepsy might reflect dysregulation of shared molecular pathways. Here we propose to use high-throughput genetic screens using ASD- and epilepsy-associated genes during mouse cortical development, followed by identification of the functional impact of such perturbation and antisense oligonucleotide rescue of the observed phenotypes. Together, it will provide a first functional account of shared dysregulated molecular pathways of ASD and epilepsy.