Innovative strategies against multispecies biofilms infections of the lung: combinations of antibiotics with phages and/or mucolytic agents

Projet de Françoise Van Bambeke soutenu par le Fonds A & J Forton et muco.be : 'Lung infection in CF are difficult to treat because of resistance and biofilm-related tolerance to antibiotics. We will evaluate in biofilm models the potential synergy between antibiotics and mucolytic agents and phages, which could contribute to disturb the biofilm matrix and kill bacteria respectively. We will study the mechanism of these synergies. We will explore the co-evolution of bacteria and phages in biofilms. We will examine the transcriptome and metabolome of biofilms'